HSMB 40: Computer Applications
This course reviews the usefulness of computers for home or business. Students learn the current Microsoft Word Program; Excel, Power Point and the preparation of a Web page and databases. Extensive "hands-on" computer use is involved for the completion of this course.
Cross-referenced courses: HIM 53 and HPA 20, CSC 6
Fall & Spring: 3 credits

HSMB 49: Laboratory Information Systems
This course describes the selection and evaluation of Laboratory Information Systems (LIS) to coordinate and interface departments of Clinical and Anatomical Pathology in the hospital setting. Problems concerning needs analysis, cost, value of the system and communication through computer technology are addressed. The usefulness of computer operations in charting, graphing, database analysis and on-line Internet services is also presented. Students identify criteria to be considered to evaluate the success of LIS systems, quality management and their competency.
Prerequisite: HSMB 40
Spring: 1 credit

HSMB 50: Clinical Chemistry I and Urinalysis
This course introduces students to safety principles, quality control and laboratory math and the analysis, quantitation, physiologic and pathologic assessment of the serum and urine specimen. Emphasis is based on the clinical correlations and analytical procedures commonly performed on serum to determine the quantity of carbohydrates, lipids, proteins, enzymes, and non-protein nitrogen substances and to assess cardiac, liver, renal, pancreatic and gastrointestinal function. Analysis of the physical, chemical and microscopic examination of urine (urinalysis) is also presented along with the disease processes that hinder kidney function.
Prerequisites: Biology 7 or 103 and Chemistry 25
Spring: 4 credits

HSMB 51: Pharmacology
The study of drugs or poisons and their effect to correct abnormal body function is presented. Emphasis is placed on the use of drugs to therapeutically treat disease and the consequence or expectation of body changes possible with their continued use. The Pharmacokinetics, Pharmacology and Pharmodynamics of drugs in common use to treat disorders is also discussed.
Prerequisite: CHM 22
Spring: 3 credits

HSMB 63: Introduction to Hematology/Phlebotomy
This course is an introduction to the methodologies, instrumentation and OSHA regulations within a clinical hematology lab. Collection and preservation of blood specimens, description of all formed cellular elements, analysis of blood smears and classification of hematological disorders, such as the anemias and leukemias are discussed. The clinical significance of sedimentation rates and reticulocyte counts and proper phlebotomy techniques and theory are also identified. Safety regulations for blood collection, universal precautions and patient preparation ethics, confidentiality and patient rights are addressed. Practice and competency in phlebotomy is required for course completion.
Prerequisite: Biology 8 or 104
Co-requisite: Chemistry 4 or permission of the instructor
Spring: 3 credits

HSMB 80: Immunology
This course is an introduction to Immunology and Immunochemistry. Structures, reaction and biological effects or antigens, antibodies and complement in the body and in vitro are discussed. Cells of the immune and inflammatory responses, their structure, functions and inter-relationships in normal individuals and in disease states is also presented.
Pre/co-requisite: Organic Chemistry or Biochemistry or permission of the instructor
Fall: 3 credits

HSMB 87: Clinical Immunology/Writing Acrosst the Curriculum
In addition to reviewing the cells and tissues of the immune system, specific and non-specific mechanisms of the immune response, the major histo-compatibility complex, hypersensitivities and tumor surveillance of the immune system, this course emphasizes immunologic techniques in the serologic identification of antigens and antibodies. Emphasis is made on measurement of the immune product or reaction which can yield significant information in the clinical differential diagnosis or monitoring the progress of a disorder / disease.
Prerequisite: HSMB 80
Spring: 3 credits

HSMB 90: Microbiology in Health Sciences
Required for all medical biology majors and health related majors including those students seeking graduate study in the biological sciences and those seeking admission into professional schools. Introducing the principles of clinical microbiology and characteristics of microorganisms, host-parasite relationships, resistance, immunity, hypersensitivity, public health, epidemiology, as well as applied, medical and industrial microbiology. Including clinical diagnostic methods such as culture, control, identification, sterilization, microbiological techniques and concepts, and emphasizes those techniques specifically employed in the clinical microbiological laboratory.
Laboratory Fee
Fall and Spring: 4 credits

HSMB 97: Virology
Viral structure, mode of infection of human cells, replication and classification are discussed. The DNA and RNA viruses associated with human diseases as well as the resultant clinical syndromes; diagnostic procedures used to collect and detect viral antigens in clinical specimens; viral serology; viral culture and storage are also presented.
Prerequisite: Biology 7, 8 or BIO 103, 104
Fall: 1 credit

HSMB 147: Management, Supervision, Teaching Seminar
This Management, Supervision and Teaching seminar identifies the five components of Management in Laboratory Medicine: duties and responsibilities including problem solving-decision-making processes; concepts of managerial leadership: communication skills; process of personnel administration: evaluation of employee performance; effective laboratory operations and principles of laboratory finance: cost containment. Additionally, information about teaching, professionalism, supervision, regulatory agency requirements, laboratory information systems, and the importance of continuing medical education are discussed. Case study assignments reflect typical laboratory problems encountered. Teaching principles include writing of objectives: Educational Methodology.
Spring: 2 credits

HSMB 150: Clinical Chemistry II & Instrumentation
This Clinical Chemistry Course is a sequel of HSMB 50. It presents topics addressing endocrinology, electrolyte and acid/base balance, porphyrins, vitamins and nutrition status, therapeutic drug monitoring, toxicology and identification of tumor markers. The clinical correlations, analytical methods commonly performed on serum or urine are discussed with an emphasis on evaluating the patient's health care status. The principles of operating instrumentation used in clinical chemistry laboratories including point of care testing devices is also presented.
Prerequisite: HSMB 50
Fall: 4 credits

HSMB 161: Hematology and Body Fluids
The formed elements of the peripheral blood, their precursors, function and structure including basic methodologies for quantitation of cells and cellular components are discussed. Normal and abnormal cellular morphologies, their clinical relevance in both the quantitative and qualitative assessment of disease in blood is also emphasized. Other body fluids are also addressed: cerebrospinal, synovial, pericardial, peritoneal, pleural, amniotic fluids and seminal fluid in terms of normal and abnormal findings, methods of collection and assessment.
Prerequisite: HSMB 63
Fall: 3 credits

HSMB 162: Coagulation
The mechanism of Blood Coagulation/Hemostasis is discussed including evaluation of bleeding disorders and thrombosis. Case studies identify the diagnostic evaluation of normal and disease states.
Prerequisite: HSMB 63
Fall: 2 credits

HSMB 185: Immunohematology/Writing Across the Curriculum
Theoretical aspects of immunohematology (blood banking) with emphasis on laboratory techniques used in blood banking is presented. Students completing this course perform techniques in actual use in the characterization of blood in hospital blood banks.
Prerequisites: HSMB 80 and 87
Fall: 4 credits

HSMB 191 Clinical Bacteriology
The study of the bacteria that are medically important to man with emphasis on identification of clinically significant pathogens distinguished from members' of the normal flora are described. Methods of isolation, identification and characterization of bacteria are integral components of this course.
Prerequisites: HSMB 90 or its equivalent and HSMB 97
Fall: 3 credits

HSMB 194: Mycology and Parasitology
This course introduces the student to the science of Mycology and Parasitology. It addresses the pathogenesis, clinical manifestations and laboratory diagnosis of medically important fungi and parasites. Emphasis is given to the differential characteristics in the identification and clinical diagnosis of mycotic and parasitic diseases. The laboratory component of this course introduces students to various diagnostic techniques used to identify these eukaryotic organisms.
Prerequisite: HSMB 90
Spring: 3 credits

HSMB 212: Pathophysiology II
This course extends a student's comprehension of disease processes by presenting the molecular, biochemical and metabolic events which identify a disease or disease process affecting several body systems.
Prerequisite: HSMB 20
Spring: 3 credits

HSMB 225: Histopathology of Body Systems
The student comprehends the magnitude of changes that occur in diseased cells and tissues of the human body that are diseased. Emphasis is on major changes observed in tissues undergoing pathologic processes such as: Inflammation, degenerations, necrosis, growth disorders; those changes that occur that influence the health and function of normal tissues within various body systems. Examination of pathology slides is an essential course requirement.
Prerequisites: Biology 7 and 8, or BIO 103 and 104, HSMB 20
Fall: 3 credits

Courses taught at Memorial Sloan-Kettering Cancer Center (HSMB 230-239)

HSMB 230: Microscopic Evaluation I (weeks 1-20)
In this course students learn to use the light microscope for the purpose of detecting and diagnosing benign, pre-malignant and malignant processes in specimens collected for cytologic evaluation.
Fall: 4 credits

HSMB 231: Microscopic Evaluation II and III (weeks 21-52)
Students continue to develop and refine microscopic skills needed to detect and diagnose benign, pre-malignant and malignant processes in gynecologic and non-gynecologic cytology specimens. Under the guidance of experienced, certified cytotechnologists, students screen actual routine specimens gaining competent microscopic skills and gradually acquiring accuracy and speed. Experience screening specimens from all body sites is gained.
Spring: 6 credits

HSMB 232: Laboratory Techniques I, II, III (weeks 1-52)
Students learn and apply the basic principles of cytopreparation using established preparatory techniques. They first observe and then assist cytopreparatory technicians processing specimens. Students gain practical experience in the operation of a cytopreparatory laboratory.
Spring: 4 credits

HSMB 233: Gynecologic Cytology (weeks 1-13)
This course covers the principles of normal and abnormal gynecologic cytopathology. Didactic and microscopic instruction focuses on basic anatomy, embryology, histology, physiology, pathology, endocrinology, and diagnostic cytopathology of the normal, infectious, inflammatory, premalignant, and malignant pathologic processes of the Female Genital Tract. Emphasis is on microscopic diagnostic features that distinguish benign cytopathologic changes from precancerous and malignant changes.
Fall: 4 credits

HSMB 234: Research Seminar (Weeks 1-52)
This course introduces students to research methods that can be applied to cytology. Students gain experience searching, critically reviewing and critiquing the scientific literature. Discussions of recent advances and progressive technological applications in cytology such as: image analysis, flow cytometry, electron microscopy, and molecular diagnostic procedures. Topics are selected for development of individual research projects.
Spring: 2 credits

HSMB 235: Urinary/Body Fluid Cytology (weeks 21-31)
This course covers the principles of normal and abnormal urinary and body cavity fluid cytopathology. Didactic and microscopic instruction focuses on basic anatomy, embryology, histology, physiology, pathology and diagnostic cytopathology of normal, benign, infectious, inflammatory, and malignant pathologic processes in various cytologic specimens. Emphasis is on microscopic diagnostic features that distinguish benign from malignant cytopathologic changes. Cytologic interpretation is correlated with tissue biopsy whenever possible.
Fall: 3 credits

HSMB 236: Pulmonary Cytology (weeks 14-20)
This course covers the principles of normal and abnormal pulmonary cytopathology. Didactic and microscopic instruction focuses on basic anatomy, embryology, histology, physiology, pathology and diagnostic cytopathology of the normal, benign, infectious, inflammatory, and malignant pathologic processes of the upper and lower respiratory system. Emphasis is on microscopic diagnostic features that distinguish benign from malignant cytopathologic changes.
Fall: 3 credits

HSMB 237: Gastrointestinal Cytology (weeks 32-36)
This course covers the principles of normal and abnormal gastrointestinal cytopathology. Didactic and microscopic instruction focuses on basic anatomy, embryology, histology, physiology, pathology and diagnostic cytopathology of normal, benign, infectious, inflammatory, and malignant pathologic processes of the gastrointestinal system in various cytologic specimens. Emphasis is on microscopic diagnostic features that distinguish benign cytopathologic from malignant changes. Cytologic interpretation is correlated with tissue biopsy whenever possible.
Spring: 1 credit

HSMB 238: Fine Needle Aspiration Cytology (weeks 37-41)
This course covers the anatomy, histology, pathology, and cytopathology of the following non-gynecologic sites: breast, lung, bone, thyroid, salivary gland, lymph node, liver and pancreas. The course focuses on cytomorphology of fine needle aspiration specimens obtained from superficial and deep lesions of the body. Pertinent clinical data, cytomorphology, and appropriate clinical management of patients affected with neoplastic lesions from these body sites are correlated. Cytologic interpretation is correlated with tissue biopsy whenever possible.
Spring: 2 credit

HSMB 239: Laboratory Management and Operations (weeks 27-32)
This basic course in Laboratory Management includes approaches to management, laboratory operations and ethics. The concepts of quality control, quality assurance, laboratory safety, and continuing education as they apply to cytology are presented. Important issues affecting the practice of cytotechnology such as federal and state regulations are presented.
Spring: 1 credit

HSMB 244: Journal Club Seminar
This course is applicable to students pursuing the Biomedical Technology Program and addresses the evaluation of research experimentation and presentation in journal format of varied biomedical problems that have been recently investigated (materials/methods used) and how the data was presented (tables, figures) by the investigators to best answer the problem studied or questions asked. In addition, the course will emphasize recent trends in research within a particular technology area.
Spring: 1 credit

HSMB 248: Undergraduate Research Project
This course serves as the culminating experience for students in the Biomedical Technology degree program. Students select a mentor to pursue a hands-on laboratory research project which investigates a Biomedical problem or question. They are then expected to analyze the data obtained and submit to the department and the mentor a written copy of the research project in a format consistent with that of a scientific publication/thesis.
Prerequisites: HSMB 40 and 49
Co-requisites: MTH 19
Spring: 4 credits

HSMB 249: Bioinformatics
This course addresses computational techniques used to study three-dimensional structures and orientation of macromolecules within biological systems. The subject enables students to work on a research life science problems and develop applications employed computerized biological images. Both areas of interest rely on proficiency in the use of the World Wide Web data. Training in bioinformatics is a Prerequisite to the comprehension of information regarding the function of genes, proteins, and numerous cellular components. Comprehension about bioinformatics enhances the qualification of graduates in biomedical sciences by allowing them to meld computer skills with current information about the special relationships of biomolecules in living systems.
Prerequisites: HSMB 40 and 49
Co-requisite: BIO 141
Fall: 3 credits

HSMB 256: Diagnostic Techniques in Molecular Pathology
Molecular diagnostics is the application of methods in biotechnology to assist in the diagnosis of disease at the cellular level. Biotechnology involves techniques used in molecular biology that are applied to the study of abnormal cells. Techniques used in biotechnology are: cell culture, the polymerase chain reaction (PCR), immunohistochemistry, cloning and genetic probes. Formal lectures are followed by experiments in a laboratory equipped to perform some of the aforementioned techniques. Additionally, the use of the internet will be demonstrated as a means of accessing databases.
Prerequisites: HSMB 80
Spring: 4 credits

HSMB 259: Practicum in Clinical Chemistry
The student works at the laboratory bench in clinical chemistry under the direct supervision of a certified clinical laboratory scientist and receives review of routine and specialized procedures. The assessment of results obtained from clinical specimens and their diagnostic significance regarding the patient/client health status is determined. Maintenance and operation of relevant instrumentation in chemistry is also addressed. (This course is eight hours/day, five days/week for six weeks=240 hrs. total practicum time).
Spring: 3 credits

HSMB 269: Practicum in Hematology and Coagulation
The student works at the laboratory bench in Hematology and Coagulation under the direct supervision of a certified clinical laboratory scientist and receives review of routine and specialized procedures. This course also reviews a routine urinalysis, other body fluid analyses, automated instrumentation in hematology and phlebotomy techniques. (This course is eight hours/day, five days/week for six weeks=240 hrs. total practicum time)
Spring: 3 credits

HSMB 271 Forensic Science Internship
This course provides the culminating experience for the Forensic Science degree.  Students are expected to critically employ evidence collected at a crime scene, analyze the results which may include: document collection, chemistry and toxicological evidence, serology, photography, and microscopy and report their assessment of the findings to determine how the crime was committed.  Students will be given pieces of evidence to assemble and describe the possible circumstances that have occurred which led to the crime. A final report of the internship work is required. Internship placements are internal (on-campus) or external at an approved forensic facility. External placements are dependent on availability and with the approval of the Clinical Director. Two hundred hours are expected for this supervised practical internship.
Prerequisites:  HSMB 71, 256 and CHM 39.
Every Semester, 2 Credits

HSMB 289: Practicum in Immunohematology
The student works at the laboratory bench in Immunohematology (Blood Banking) under the direct supervision of a certified clinical laboratory scientist and receives review of blood banking techniques/ procedures and serologic methods used for clinical diagnosis of principle disorders. This course also reviews routine instrumentation use and its standardization in performing blood banking methods. (This course is eight hours/day, five days/week for six weeks=240 hrs. total practicum time)
Spring: 3 credits

HSMB 299: Practicum in Microbiology
The student works at the laboratory bench in Microbiology under the direct supervision of a certified clinical loratory scientist and receives review of clinical bacteriology, clinical virology, mycology and parasitology techniques/ procedures used for the clinical specimen isolation, cultivation and identification for diagnosis of disease. Utilization of equipment and instrumentation used in Microbiology is also presented. (This course is eight hours/day, five days/week for six weeks=240 hrs. total practicum time)
Spring: 3 credits

HSMB 511 Biomedical Ethics
This course is a general survey of the ethical issues relevant to the human life cycle. Topics such as organ transplants, termination of life, euthanasia, abortion, genetic control, and medical experimentation are discussed. This course is geared primarily for individuals with a background or interest in the health and medical sciences such as medical technologists, radiologic technologists, nurses, health care administrators and other professionals in the health field.
On Occasion, 3 Credits

HSMB 513/BIO 513 Biochemistry
This course is an inquiry into the chemistry of biologically important compounds including amino acids, proteins, lipids, carbohydrates, nucleic acids, vitamins, biological oxidation, intermediary metabolism and enzyme systems.
Fall and Summer, 3 Credits

HSMB 520/520C Pathophysiology I
This graduate course introduces the student to human disease processes. The biochemical effects of the diseases as they relate to normal metabolism are also considered. Not required of students who have had an undergraduate class in pathophysiology.
Formerly HSMB 611
Fall, 3 Credits

HSMB 540/540C/HSN 540 Biomedical Statistics
This course covers the fundamentals of statistics as applied to medical and biological sciences including: measures of central tendency and variability, theory of sampling, theory of estimation, sample frequency functions, confidence limits, null hypothesis, linear regression and correlation, chi-square test, F-Test and analysis of variance, elements of sequential analysis, statistical techniques adapted to laboratory quality control and design of experiments.
Alternate Spring, 3 Credits

HSMB 541/HSN 541 Computer Applications in Health Sciences
This course is an introduction to the use of computers in the various fields of the health sciences. Review of statistical applications for data analysis is also included.
Term project required.
Fall, 3 Credits

HSMB 542 Epidemiology
This course is an introduction to epidemiologic principles employed in the investigation of disease. A review of public health statistics in relation to disease rates and evaluation of community efforts toward the reduction of these rates is considered. The use of epidemiologic investigations of chronic physical and mental disease is discussed.
On Occasion, 3 Credits

HSMB 549 Resources Management
Resources Management is a course which addresses important topics in two areas of Laboratory Management: physiscal and human resourses both of which are essential for professional maintenance and growth of a clinical laboratory. Topics addressed in physical resources include: the accreditation process, certification and licensure of laboratory health professionals; laboratory policies and procedures, workload recording, budgets, purchasing and inventory control, laboratory design, space utilization and laboratory safety. Human resources topics involve the actual clinical laboratory organization, job descriptions, recruitment, hiring and orientation of laboratory personnel. The course emphasis is to highlight those laboratory resource issues in management that professionals must address in their daily work environment to recognize the problems and formulate their solution.
Fall, 3 Credits

HSMB 550/550C Medical Chemistry
This course is the introduction to the analysis of analyates in body fluids. Emphasis is placed on describing normal and pathophysiologic changes in disease. Quality control, evaluation, interpretation and laboratory tests used in quantitation are presented. The biomedical significance of metabolic disorders of proteins, carbohydrates and lipids is discussed.
Fall, 3 Credits

HSMB 555 Instrumentation for the Clinical Laboratory
This course is a study of current principles of automated instrumentation analyses performed in the clinical laboratory. The course provides practical exposure to several commercially available systems.
Spring, 3 Credits

HSMB 561/561C Introduction to Hematology
This course is a study of hematopoiesis (red blood cell development) in the embryo and the adult. Diseases of the blood-forming organs are stressed. Laboratory experiences emphasize procedures necessary for diagnosis of disease of blood-forming tissues.
Fall, 3 Credits

HSMB 562/562C Theories of Blood Coagulation
This course covers the theoretical aspects of blood coagulation in normal and disease states, including laboratory methods which demonstrate various blood factors.
Spring, 3 Credits

HSMB 574 Tissue Culture
This course includes the study methods and media for the in-vitro proliferation and maintenance of vertebrate tissue and its application to experimental methods in histology, pharmacology and medical technology.
On Occasion, 3 Credits

HSMB 580 Immunology: Theory and Laboratory Applications
This course covers the principles of immunology, including: immunity as a protective mechanism, immunochemistry, cells and organs of the immune system and immunologic disease states. The laboratory emphasizes serologic and other immunologic techniques for disease diagnosis.
Not open to students who have completed HSMB 581.Alternate Fall, 3 Credits

HSMB 581 Immunology Lecture
This course covers the principles of immunology including immunity as a protective mechanism, immunochemistry, cells and organs of the immune system and immunologic disease states. Current journal articles describing the role of various cell types in viral, bacterial, malignant, autoimmune and allergic disease are discussed.
Not open to students who have completed HSMB 580.
Alternate Fall, 3 Credits

HSMB 585 Immunohematology
This course covers a historical perspective of theoretical aspects and laboratory techniques of immunohematology with emphasis on various blood group systems.
Spring, 3 Credits

HSMB 591 Medical Microbiology
This course serves three purposes: (1) as a "refresher" course to those who are in the field; (2) as a prerequisite for further study in microbiology; and (3) as preparation for professional board examinations. The delineation of microbial species: bacteria, fungi, algae, viruses, rickettsiae, chlamydia, protozoa, helminths and other animal parasites implicated in disease is presented. The course covers methods used in diagnostic microbiology as well as medical, clinical, epidemiological and nosocomial aspects of microbial disease states. Additionally, computerization, instrumentation, miniaturization, and DNA recombinant studies applicable to microbiology are covered.
Fall, 3 Credits

HSMB 594 Medical Parasitology
This course examines host-parasite relationships relative to disease transmission, pathology, immunology, epidemiology, survey and control. Emphasis on laboratory preparations and diagnosis of parasitic diseases includes those aspects of life cycles that are useful for clinical diagnosis.
Alternate Fall, 3 Credits

HSMB 595 Zoonoses
Diseases of feral and domesticated animals communicable to man, which include bacterial, mycotic, rickettsial, chlamydial, viral, protozoal and helminthic infections are examined. Vectors associated with zoonoses are reviewed. The public health and the epidemiology of the diseases and the procedures used to prevent and control human and animal infection are stressed. Overpopulation of animals as a threat to health and the sociological implications of pet ownership are also discussed.
On Occasion, 3 Credits

HSMB 612/612C Pathophysiology II
Molecular, biochemical and metabolic events which identify disease of several body systems are presented.
Prerequisite: HSMB 520 or equivalent
Spring, 3 Credits

HSMB 647 Quality Management for the Clinical Laboratory
This course addresses the implementation of quality improvement principles for the Clinical Laboratory. It begins with a discussion of the rational about continuous quality improvement, the group or teamwork approach to quality improvement, and the process of formulating flowcharts, matrices and quality control charts to analyze and Quantitate quality improvement measures. It ends by discussing and responding to actual case situations by utilizing clinical practice guidelines that help to understand the nature of disease processes and outcomes of early interventions.
Spring, 3 Credits

HSMB 648 Microbial Physiology
This course examines the metabolic activities of bacteria and fungi. Emphasis is placed on the bacterial cell, enzymes, energy, respiration, fermentation, metabolism, synthesis, catabolic, anabolic and amphibolic pathways. Microbiological assays, spectrophotometry, complete fermentation study and other procedures utilizing basic and advanced techniques and equipment are included.
Collateral readings and term report are required.
On Occasion, 3 Credits

HSMB 650 Advanced Medical Chemistry
This is an advanced course designed to provide in-depth understanding of the medical approach to evaluating disorders. Several topics are presented for review, analysis and discussion. This course also has a laboratory component which provides further emphasis about medically significant analytes.
Alternate Summer, 3 Credits

HSMB 651/651C Pharmacology
The application of pharmacology, the study of drugs and poisons, is termed therapeutics. To better understand the use of drugs in specific disease states, therapeutics is emphasized in this course. The student develops an understanding of the disease process being treated, and any concomitant diseases the patient may have. The consequences and expectations of the drugs being administered (considering its pharmacodynamics, pharmacognosy and pharmacokinetics) in that specific patient are presented.
Spring or Summer, 3 Credits

HSMB 655 Toxicology and Therapeutic Monitoring
This course covers the instrumental methods of assay. Toxicologic and pharmacologic action on and by the host organism are examined along with a review of major drug and toxin types. Special topics of interest are covered in the detection and identification of drugs in biological fluids.
Alternate Fall, 3 Credits

HSMB 656 Diagnostic Techniques in Molecular Pathology
Molecular diagnostics is the application of methods in biotechnology to the diagnosis of disease. Biotechnology involves techniques used in molecular biology as applied to the study of cell function at the DNA/RNA level. This course surveys some of the standard techniques used in biotechnology: cell culture, polymerase chain reaction (PCR), immunohistochemistry, cloning and probe synthesis. Formal lectures are followed by experiments in a laboratory equipped to perform some of the aforementioned techniques. Most of these techniques represent transferable technologies that may be used in various fields; i.e., forensic pathology, clinical laboratory medicine and cancer screening.
Fall or Spring, 3 Credits

HSMB 661 Advanced Hematology
In-depth coverage of concepts of cell origin and differentiation, as well as the molecular concepts of disease and current trends in research are covered. Quality control experience in lab practice, marrow differential counts, histochemical and biochemical techniques are included in-depth.
Alternate Spring, 3 Credits

HSMB 665 Experimental Hematopoiesis
This course includes the development of techniques in experimental hematopoiesis primarily on mammalian bone marrow. Instruction of students in techniques of altering hematopoiesis and evaluation of results is also included.
Alternate Spring, 3 Credits

HSMB 673 Cancer Research: Perspectives, Prospects and Problems
This course covers the assessment of the effects of various biological disciplines; i.e., genetics, biochemistry, virology, endocrinology, pathology, pharmacology, hematology and immunology upon past and present efforts in cancer research. Lectures and demonstrations are included.
Alternate Fall, 3 Credits

HSMB 687 Advanced Immunology
This course examines immunology with emphasis on current areas of research. Isolation, chemical analysis and structure, and interactions of antigens and antibodies are studied in conjunction with assays of immunological activity.
Prerequisite: HSMB 580 or 581 or undergraduate immunology
Alternate Spring, 3 Credits

HSMB 688 Laboratory Techniques in Immunochemistry
Lectures illustrate the quantitative and qualitative aspects of immunochemistry and state-of-the-art monoclonal developments. Laboratory exercises demonstrate molecular weight sieves, ion-exchange chromatography, affinity chromatography, gel precipitation reactions, enzymatic cleavage of antibodies, labeling of antibodies and enzyme immunoassay procedures.
on occasion, 3 Credits

HSMB 691 Advanced Medical Microbiology
Isolation, identification and significance of microorganisms implicated in disease and as encountered in the clinical microbiology laboratory are covered in-depth. The significance of saprophytes found in the clinical specimen, unusual isolates and findings are discussed. Proficiency testing implemented as part of the practical microbiology, computerization, instrumentation, miniaturization and DNA recombinant studies applicable to microbiology are reviewed.
Prerequisite: HSMB 591 or by permission of instructor based on background in microbiology
Alternate Spring, 3 Credits

HSMB 696 Medical Mycology
This course is a study of the classification, identification, life cycles morphology, physiology, biochemistry and immunology of fungi of medical and clinical significance. A discussion of the fungi as microbial entities and economic importance is included. The course employs the use of microbiological techniques in the elucidation of fungi implicated in disease as encountered in the clinical microbiology laboratory as well as the identification of other fungi. Proficiency testing is discussed and implemented as part of the practical aspects of the course.
Alternate Spring, 3 Credits

HSMB 698 Medical Virology
Isolation, identification and classification of the viruses in man and animals with application to disease states such as causes, diagnosis and prevention are examined.
Prerequisite: Course in biochemistry or molecular biology
Alternate Fall, 3 Credits

HSMB 699 Laboratory Techniques in Virology
Production, purification and quantitation of viruses with analysis of virion structure and investigation of steps in viral replication are covered in this course.
Alternate Fall, 3 Credits

HSMB 700 Selected Problems in Laboratory Medicine
This course examines a research problem under the guidance of a member of the Department of Biomedical Sciences faculty. Students may register only once for this course.
1 or 2 Credits, to be determined with the approval of the chairperson, the Graduate Committee, and the mentor. Open only to matriculated students.

HSMB 703/703C Research Methods
This is a course designed to provide practical tools for initiation and development of a research proposal. The scientific approaches to problem-solving, data collection and analysis are discussed.
Prerequisite: Approved course in statistics
Fall & summer I, 3 Credits

HSMB 704/704C Clinical Research Thesis
This course is a clinical research project designed to develop and enhance research skills appropriate to the area of specialization chosen for the M.S. degree. The research data is obtained from a health care facility, academic setting, business or industry, community program, or clinical research facility. The collected data is analyzed and a thesis is written and presented to the department.
Open only to matriculated students with approval by department chairperson, Graduate Committee, and mentor.
Prerequisite: HSMB 703
Every Semester, 3 Credits

HSMB 705 Selected Topics in Medical Biology
This seminar course deals with current topics, and critiques and evaluates techniques used in an area of specialization in Medical Biology. These include Medical Chemistry, Hematology, Immunology and Medical Microbiology. Different topics are offered during an academic year.
Open only to matriculated students.
Prerequisite: Approval by instructor and Graduate Committee
Annually, 3 Credits

HSMB 706/706C Research Project
This course provides another option for successful completion of the M.S. degree in Medical Biology through the completion of a research project and a comprehensive examination in the specialty.
Open only to matriculated students with approval by department chairperson, Graduate Committee, and mentor.
Prerequisite: HSMB 703
Every Semester, 3 Credits

HSMB 707 Preparation of Thesis Proposal and HSMB 708 Experimental Research Thesis
Open only to matriculated students with approval by department chairperson, Graduate Committee, and mentor.
Special fee, $60 each course
Every Semester, 3 Credits each

HSMB 709/709C Clinical Management Project
This course is designed for the Clinical Laboratory Management M.S. degree candidate who will address a management problem within the clinical setting. Examples of some project topics include: motivation of coworkers, organization and communication improvements, measuring group effectiveness, selection criteria for employees, appraisals of laboratory personnel, staffing, development of educational activities, implementation of procedures, budgeting cost analysis, workloads, inventory management and cost-containment measures. Problems should be defined, solutions suggested and tested and a project paper (Thesis) written and defended.
Open only to matriculated students with approval of department chairperson, Graduate Committee and mentor.
Prerequisite: HSMB 703
Every Semester, 3 Credits

Hospital Based Courses in Cardiovascular Perfusion completed at North Shore University Hospital Based Courses (27 credits total)

HSMB 810C Perfusion Technology
This course combines clinical competency in perfusion techniques, didactic instruction with practical operating room experience and laboratory study of the extracorporeal circuit. The course begins with a discussion of the evolution of perfusion technology, describes the laboratory components needed, venous and arterial cannuli, flow limitations, and determination of Reynold's number. Included also are discussions of heater/cooler and heat exchanges; circulation, hypothermia, tubing, circuits, charting, pressure monitoring, arterial blood gas, electrolytes, cardiotomy reservoirs and suction systems, cardiopulmonary bypass and safety, and myocardiac protection delivery systems. The course teaches techniques, procedures, laboratory techniques, management and evaluation of the total perfusion process.
First year (Module I & II) of CVP Program
6 Credits (1152 hours Clinical Instrumentation)

HSMB 820C, 822C, 824C Clinical Practicums I, II, III
The Clinical Practicum Courses completed at North Shore University Hospital are designed to provide perfusion students with an intensive opportunity to develop, practice and master the skills required to perform safe extracorporeal circulation procedures. These clinical practice courses require directed hands-on use of equipment and techniques that constitute the cardiopulmonary bypass procedure. Under the direct supervision of a clinical instructor, the students are exposed to increasing levels of responsibility in the clinical conduct of perfusion. As the students' abilities permit, they assume expanding responsibilities with the ultimate goal of functioning independently as a practicing perfusionist. These clinical practice courses are taught in the operating room theater with special emphasis on developing technical skills in the extracorporeal procedure itself. Instruction will also include current adjunctive methods in autotransfusion, mycocardial preservation techniques, intra-aortic ballon support, and aseptic techniques.
At course completion, the student will have:
1. developed sufficient clinical
competency about the rudiments of extracorporeal circuit, its components, design, assembly and operation of the equipment.
2. under directed supervision, begun to successfully perform those technical manipulations that constitute the essential part of the extracorporeal circuit and other perfusion procedures.
3. been evaluated by the instructors supervising the clinical learning experiences. Students are evaluated by using an evaluation form titled "Perfusion Student Case Evaluation."
Following the completion of Perfusion Clinical Practice courses, each student is required to perform clinical cases for clinical competency determination. In these Clinical Competency Cases, each student's ability to function independently as a clinical perfusionist is evaluated for his or her level of training. These clinical competency evaluations are performed utilizing the standard procedures for clinical student case evaluation. In addition, the clinical instructors evaluate the entry-level clinical competency skills as required by the American Board of Cardiovascular Perfusion.
Second year (Module III & IV) of
CVP Program
5 Credits each (960 hours each -
288 hours total)